Srila Visvanatha Cakravati Thakur indicates in his Bhagavad Gita purport chap.4 text 36

That if one has been able to begin to acquire knowledge of mind , body , and consciousness to a standard of at least coming towards Brahman consciousness , ie. The clear  knowledge of the consciousness as separate from the material body , known as scientific dualism , then peace  begins to be established within the heart , hankering and lamenting begin to diminish from the heart , chasing down sense gratification begins to be less of a priority. Knowledge is acquired by regulatory life , duty, and sacrifices . The fourth chapter of the Bhagavad Gita enlightens us in all processes of sacrifice . Another key feature to knowledge and sacrifice is that it destroys Aprarabdha karma , future sufferings that were due . The karmic chain has begun to be broken . The senses are no longer functioning without control , as they were , like an unthinking animal , in terms of dualism . Senses out of control are the cause of the responsive universe awarding further karmic synchronicities along with the ethereal states of mind .

Although Aprarabdha karma is destroyed through knowledge, Prarabdha karma is not , so karmic synchronicities keep  following from previous conditioning in the current body , Prarabdha karmas , However, Bhakti sacrifices are done with pure knowledge of devotion to Krishna and they immediately reestablish  devotion and destroy both  Aprarabdha and Prarabdha karma.

Sri Caitanya Mahāprabhu has brought to this world the easiest process of sacrifices , bringing knowledge,  of pure Bhakti to Krishna.

Srila AC Bhavtivedanta Swami explains all and has spread this process of Sankirtana sacrifice all over the world, and some of the most sinful persons have very quickly become knowledgeable of pure devotion to Krishna. By Sri Caitanya Mahaprabhu mercy, a lame man can walk , a blind man can see, and a dumb man can compose eloquent poetry.

Trancendental knowledge of a higher plane , some trancendental insights into such a plane , and importantly some faith in the process along with  mercy decending from a spiritual realms ,  can carry one a long way .

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