Srila Visvanatha Cakravati Thakur indicates in his Bhagavad Gita purport chap.4 text 36

That if one has been able to acquire knowledge of mind , body , and consciousness to a standard of at least Brahman consciousness , ie. The   knowledge of the consciousness as separate from the material body , known as dualism,  then bliss and peace are established within the heart , and there is no longer hankering and lamenting  or chasing down sense gratification . Knowledge is acquired by sacrifices,  and the fourth chapter of the Bhagavad Gita enlightens us in all processes of sacrifice. Another key feature to knowledge is that it destroys Aprarabdha karma , future sufferings that were due , because the karmic chain has been broken,  the senses are no longer functioning without control like an animals. Senses out of control is the cause of the responsive universe awarding further karmic synchronicities.

Although Aprarabdha karma is destroyed through knowledge, Prarabdha karma is not , so karmic synchronicities follow from previous conditioning in the current body , however Bhakti pure knowledge of devotion to Krishna and reestablished devotion destroys Aprarabdha and Prarabdha karma.

Sri Caitanya Mahāprabhu has brought to this world the easier process of sacrifices,  of knowledge and of pure Bhakti.

Srila AC Bhavtivedanta Swami explains all and has spread this process all over the world and some of the most sinful persons have very quickly become knowledgeable of Bhakti and devotion to Krishna. By Sri Caitanya Mahaprabhu mercy, a lame man can walk , a blind man can see, and a dumb man can compose eloquent poetry.

Knowledge of a higher plane , some trancendental insights,  some faith , and some mercy decending from a spiritual realms can carry one a long way .

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