The material body is the symbol of the gross and subtle form of forgetfulness; therefore the whole atmosphere of the material world is called avidyā, or nescience, whereas the whole atmosphere of the spiritual world is called vidyā, or full of knowledge.
A C Bhaktivedanta Swami Prabhupada.
Krishna in His Bhagavad Gita clearly defines knowledge and ignorance, unless one understands how ignorance and the lower conditioning works, one will become subject to its influence, the Vedas describes the subtle conditioning that influence our consciousness, broadly described as The three modes of nature , Goodness , passion and ignorance.
These are like the three primary colours, and as an artist can create many combinations of colours, or a musician can create many melodies from ABCDEFG , similarly the mental states and motives force individuals to act in unlimited and certain ways , the lower mode of ignorance is extremely binding and predicted events can easily be worked out by someone in the extream mode of ignorance, the goodness mode has more freedoms and is less predicable, in one sense.
Someone who is spiritually advanced is never effected by these three modes of nature , that try to compete for dominance , in all individuals, even a man in ignorance can see and experience a glimpse of goodness, and a man in goodness can be momentarily effected by ignorance.
The pure representatives of Divinity are said to be in Suddha Sattva , pure goodness, trancendental to the material energies , one should seek such persons out , or research their lives and litratures , that is recommended by Divinity Himself.
So knowledge is important , but part of knowledge is having a deep insight as to what is ignorance and what is self-centred passion , spiritual consciousness is not touched by such lower contaminated conditions..